A 14-year-old girl from Nigeria, Grace Natasha Mwanasa, has undergone a successful total hip replacement surgery at Indraprastha Apollo Hospital in New Delhi. The surgery, led by renowned orthopaedic surgeon Dr. Yash Gulati, is one of the youngest cases of total hip arthroplasty in a patient with sickle cell disease. Grace was diagnosed with sickle cell disease in early childhood and had experienced recurring sickle cell crises, requiring multiple hospitalizations, ICU care, and blood transfusions.
In December 2025, Grace was admitted to Apollo Hospital with severe left hip pain, inability to walk, limping, and disturbed sleep due to constant pain. Evaluation revealed advanced avascular necrosis and complete destruction of the left femoral head, a known complication of sickle cell disease. Due to her severe pain, complete loss of hip movement, and significant functional disability, the medical team decided to proceed with total hip replacement.
The surgery required extensive preoperative planning, including an exchange blood transfusion to reduce HbS levels, which is a key component of sickle cell disease. The medical team also took precautions during anesthesia and surgery, including hydration, prevention of hypothermia, and meticulous bleeding control. The surgery was a success, and Grace is expected to recover and regain her mobility.
Dr. Gulati and his team’s expertise and careful planning were crucial in the success of the surgery. The case highlights the importance of timely and proper medical intervention in managing sickle cell disease and its complications. The surgery has given Grace a new lease on life, and she is expected to make a full recovery. The case also underscores the capabilities of Indian healthcare, with Indraprastha Apollo Hospital emerging as a hub for complex surgeries and treatments. The successful surgery has brought hope to patients suffering from sickle cell disease and other complex medical conditions, and has demonstrated the potential for effective treatment and management of these conditions with proper medical care.